Document Type

Article

Publication Date

10-1-2022

Publication Title

Dis Model Mech

Keywords

JMG, Animals, Biomedical Research, Humans, Laboratories, Mice, Reproducibility of Results, Research Design, Research Personnel

JAX Source

Dis Model Mech. 2022;15(10):dmm049775

Volume

15

Issue

10

ISSN

1754-8411

PMID

36250972

DOI

https://doi.org/10.1242/dmm.049775

Abstract

In 2021, the National Institutes of Health Advisory Committee to the Director (ACD) announced recommendations to improve the reproducibility of biomedical research using animals. In response, The Jackson Laboratory faculty and institutional leaders identified key strategies to further address this important issue. Taking inspiration from the evolution of clinical trials over recent decades in response to similar challenges, we identified opportunities for improvement, including establishment of common standards, use of genetically diverse populations, requirement for robust study design with appropriate statistical methods, and improvement in public databases to facilitate meta-analyses. In this Perspective, we share our response to ACD recommendations, with a specific focus on mouse models, with the aim of promoting continued active dialogue among researchers, using any animal system, worldwide. Such discussion will help to inform the biomedical community about these recommendations and further support their much-needed implementation.

Comments

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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