The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
Document Type
Article
Publication Date
12-1-2022
Publication Title
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Keywords
JMG, Mice, Animals, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Positron Emission Tomography Computed Tomography, Mice, Inbred C57BL, Folic Acid, Genetic Predisposition to Disease, Genotype
JAX Source
J Cereb Blood Flow Metab. 2022;42(12):2333-50
Volume
42
Issue
12
First Page
2333
Last Page
2350
ISSN
1559-7016
PMID
36050860
DOI
https://doi.org/10.1177/0271678x221122644
Grant
We would like to acknowledge funding support from the Diana Davis Spencer Foundation (Howell), BrightFocus Foundation (grant no. A2020677F) (Reagan), the Canadian Institutes of Health Research (grant no. PJT173521) (Rozen), National Institute on Aging (grant no.U54AG054345) (MODEL-AD). Collection and sharing of human data used in this study was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01AG024904) and DODADNI (Department of Defense award number W81XWH-12-2- 0012).
Abstract
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate and methionine cycles. Variants in
Recommended Citation
Reagan A,
Christensen K,
Graham LC,
Bedwell A,
Eldridge K,
Speedy R,
Figueiredo L,
Persohn S,
Bottiglieri T,
Nho K,
Sasner M,
Territo P,
Rozen R,
Howell G.
The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice J Cereb Blood Flow Metab. 2022;42(12):2333-50