The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
JMG, Mice, Animals, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Positron Emission Tomography Computed Tomography, Mice, Inbred C57BL, Folic Acid, Genetic Predisposition to Disease, Genotype
J Cereb Blood Flow Metab. 2022;42(12):2333-50
We would like to acknowledge funding support from the Diana Davis Spencer Foundation (Howell), BrightFocus Foundation (grant no. A2020677F) (Reagan), the Canadian Institutes of Health Research (grant no. PJT173521) (Rozen), National Institute on Aging (grant no.U54AG054345) (MODEL-AD). Collection and sharing of human data used in this study was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01AG024904) and DODADNI (Department of Defense award number W81XWH-12-2- 0012).
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate and methionine cycles. Variants in
The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice J Cereb Blood Flow Metab. 2022;42(12):2333-50