Document Type
Article
Publication Date
11-23-2022
Publication Title
Nutrients
Keywords
JGM, Humans, Female, Mice, Animals, Osteoporosis, Postmenopausal, Bone Density, Double-Blind Method, Ribes
JAX Source
Nutrients. 2022;14(23):4971.
Volume
14
Issue
23
ISSN
2072-6643
PMID
36501004
DOI
https://doi.org/10.3390/nu14234971
Grant
This research was funded by the USDA NIFA Seed Grant to Ock K. Chun (#2020-67018- 30852) and the University of Connecticut Foundation Esperance Funds to O.K.C. We thank Just the Berries Ltd. for providing the blackcurrant extract.
Abstract
Beneficial effects of blackcurrant supplementation on bone metabolism in mice has recently been demonstrated, but no studies are available in humans. The current study aimed to examine the dose-dependent effects of blackcurrant in preventing bone loss and the underlying mechanisms of action in adult women. Forty peri- and early postmenopausal women were randomly assigned into one of three treatment groups for 6 months: (1) a placebo (control group, n = 13); (2) 392 mg/day of blackcurrant powder (low blackcurrant, BC, group, n = 16); and (3) 784 mg/day of blackcurrant powder (high BC group, n = 11). The significance of differences in outcome variables was tested by repeated-measures ANOVA with treatment and time as between- and within-subject factors, respectively. Overall, blackcurrant supplementation decreased the loss of whole-body bone mineral density (BMD) compared to the control group (p < 0.05), though the improvement of whole-body BMD remained significant only in the high BC group (p < 0.05). Blackcurrant supplementation also led to a significant increase in serum amino-terminal propeptide of type 1 procollagen (P1NP), a marker of bone formation (p < 0.05). These findings suggest that daily consumption of 784 mg of blackcurrant powder for six months mitigates the risk of postmenopausal bone loss, potentially through enhancing bone formation. Further studies of larger samples with various skeletal conditions are warranted to confirm these findings.
Recommended Citation
Nosal B,
Sakaki J,
Macdonald Z,
Mahoney K,
Kim K,
Madore M,
Thornton S,
Tran T,
Weinstock GM,
Lee E,
Chun O.
Blackcurrants Reduce the Risk of Postmenopausal Osteoporosis: A Pilot Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Nutrients. 2022;14(23):4971.
Comments
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).