NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Document Type

Article

Publication Date

12-1-2022

Publication Title

Nat Aging

Keywords

JGM, United States, Humans, Longevity, Cellular Senescence, Biomarkers

JAX Source

Nat Aging . 2022 Dec;2(12):1090-1100.

Volume

2

Issue

12

First Page

1090

Last Page

1100

ISSN

2662-8465

PMID

36936385

DOI

10.1038/s43587-022-00326-5

Grant

This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards: U54AG075932 (to J.C. and B.S.), UG3CA268112 (to H.D.-L.), U54AG075934 (to L.D. and F.C.), UG3CA268117 (to Z.D.), U54AG076043 (to R.F. and S.H.), U54AG075931 (to T.F., M.K., A.L.M., O.E., M.R. and I.R.), UG3CA268096 (to L.G.), U54AG075941 (to G.K., V.G., N.M. and P.R.), UG3CA268091 (to J.H.L.), U54AG075936 (to P.J.L.), UG3CA268105 and U54AG075932 (to S.M.), UG3CA268202 (to N.N., S.W. and J.M.), U54AG076041 (to L.J.N. and C.F.A.), UG3CA268103 (to J.F.P.), U54AG076040 (to H.P.) and U24CA268108 (to J.C.S., Z.B.-J. and P.B.). We thank V. Bekker, SCENT Program Manager for administrative and formatting assistance. We also thank D. Mathias, Science Illustrator, for assistance with figures.

Abstract

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.

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