Document Type

Article

Publication Date

7-29-2022

Publication Title

G3 (Bethesda, Md.)

Keywords

JMG, GWAS, MPP, QTL mapping, genome-wide association studies, multiparental populations, quantitative trait loci mapping

JAX Source

G3 (Bethesda) . 2022 Jul 29;12(8):jkac146.

Volume

12

Issue

8

PMID

35703938

DOI

10.1093/g3journal/jkac146

Grant

This work was supported by the Jackson Laboratory Cube Initiative and grant funding from the National Institute of Health (NIH): R01GM070683 (GAC and KWB), F32GM134599 (GRK), R01DK101573 (MPK), and RC2DK125961 (MPK). This work was also supported by the University of Wisconsin–Madison, Department of Biochemistry and Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation (MPK).

Abstract

The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross and Diversity Outbred studies, increasing the accessibility of these genetic resources to the broader scientific community.

Comments

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited

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