The Cardiac Sarcomere and Cell Cycle
Document Type
Article
Publication Date
6-1-2022
Publication Title
Current cardiology reports
Keywords
JGM, Cell cycle, Heart failure, Regeneration, Sarcomere
JAX Source
Curr Cardiol Rep . 2022 Jun;24(6):623-630.
Volume
24
Issue
6
First Page
623
Last Page
630
PMID
35380383
DOI
10.1007/s11886-022-01682-9
Grant
J.T.H. is supported by the National Institutes of Health (HL142787 and EB028898). A.M.P. and F.A.L. are supported by the American Heart Association (PRE34381021 and PRE35110005).
Abstract
PURPOSE OF REVIEW: The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms. RECENT FINDINGS: This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms. Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation.
Recommended Citation
Pettinato AM,
Ladha FA,
Hinson J.
The Cardiac Sarcomere and Cell Cycle Curr Cardiol Rep . 2022 Jun;24(6):623-630.