Document Type

Article

Publication Date

3-1-2022

Publication Title

Mammalian genome : official journal of the International Mammalian Genome Society

Keywords

JMG

JAX Source

Mamm Genome 2022 Mar; 33(1):55-65

Volume

33

Issue

1

First Page

55

Last Page

65

ISSN

1432-1777

PMID

34482425

DOI

https://doi.org/10.1007/s00335-021-09909-w

Grant

OD011190, HD062499

Abstract

Recombinase alleles and transgenes can be used to facilitate spatio-temporal specificity of gene disruption or transgene expression. However, the versatility of this in vivo recombination system relies on having detailed and accurate characterization of recombinase expression and activity to enable selection of the appropriate allele or transgene. The CrePortal ( http://www.informatics.jax.org/home/recombinase ) leverages the informatics infrastructure of Mouse Genome Informatics to integrate data from the scientific literature, direct data submissions from the scientific community at-large, and from major projects developing new recombinase lines and characterizing recombinase expression and specificity patterns. Searching the CrePortal by recombinase activity or specific recombinase gene driver provides users with a recombinase alleles and transgenes activity tissue summary and matrix comparison of gene expression and recombinase activity with links to generation details, a recombinase activity grid, and associated phenotype annotations. Future improvements will add cell type-based activity annotations. The CrePortal provides a comprehensive presentation of recombinase allele and transgene data to assist researchers in selection of the recombinase allele or transgene based on where and when recombination is desired.

Comments

We would like to thank Joel Richardson, Richard Balderelli, and the rest of the MGI software team for their support for the CrePortal work presented here.

This article is licensed under a Creative Commons Attribution 4.0 International License.

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