Macrophages in dermatology: pathogenic roles and targeted therapeutics.
Document Type
Article
Publication Date
3-1-2022
Publication Title
Archives of dermatological research
Keywords
JMG, Humans, Lymphoma, T-Cell, Cutaneous, Macrophages, Psoriasis, Skin Neoplasms, Wound Healing
JAX Source
Arch Dermatol Res 2022 Mar; 314(2):133-140
Volume
314
Issue
2
First Page
133
Last Page
140
ISSN
1432-069X
PMID
33641015
DOI
https://doi.org/10.1007/s00403-021-02207-0
Abstract
The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.
Recommended Citation
Kuraitis D,
Rosenthal N,
Boh E,
McBurney E.
Macrophages in dermatology: pathogenic roles and targeted therapeutics. Arch Dermatol Res 2022 Mar; 314(2):133-140