Title

Macrophages in dermatology: pathogenic roles and targeted therapeutics.

Document Type

Article

Publication Date

3-1-2022

Publication Title

Archives of dermatological research

Keywords

JMG, Humans, Lymphoma, T-Cell, Cutaneous, Macrophages, Psoriasis, Skin Neoplasms, Wound Healing

JAX Source

Arch Dermatol Res 2022 Mar; 314(2):133-140

Volume

314

Issue

2

First Page

133

Last Page

140

ISSN

1432-069X

PMID

33641015

DOI

https://doi.org/10.1007/s00403-021-02207-0

Abstract

The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.

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