A novel clinically relevant graft-versus-leukemia model in humanized mice.
Document Type
Article
Publication Date
2-1-2022
Publication Title
Journal of leukocyte biology
Keywords
JMG, Animals, Disease Models, Animal, Graft vs Leukemia Effect, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Acute, Mice, Mice, Inbred NOD, Mice, SCID, Transplantation, Homologous
JAX Source
J Leukoc Biol 2022 Feb; 111(2):427-437.
Volume
111
Issue
2
First Page
427
Last Page
437
ISSN
1938-3673
PMID
34057741
DOI
https://doi.org/10.1002/jlb.5ab0820-542rr
Abstract
The prognosis for acute myeloid leukemia (AML) relapse post allogeneic hematopoietic stem cell transplantation (alloSCT) is dismal. Novel effective treatment is urgently needed. Clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. The mechanisms that mediate immune escape of leukemia (thus causing GVL failure) remain poorly understood. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. Here, using our large, longitudinal clinical tissue bank that include AML cells and G-CSF mobilized donor hematopoietic stem cells (HSCs), we successfully established a novel GVL model in humanized mice. Donor HSCs were injected into immune-deficient NOD-Cg-Prkdc
Recommended Citation
Jia B,
Zhao C,
Bayerl M,
Shike H,
Claxton D,
Ehmann W,
Mineishi S,
Schell T,
Zheng P,
Zhang Y,
Shultz LD,
Prabhu K,
Paulson R,
Zheng H.
A novel clinically relevant graft-versus-leukemia model in humanized mice. J Leukoc Biol 2022 Feb; 111(2):427-437.