Title

A novel clinically relevant graft-versus-leukemia model in humanized mice.

Document Type

Article

Publication Date

2-1-2022

Publication Title

Journal of leukocyte biology

Keywords

JMG, Animals, Disease Models, Animal, Graft vs Leukemia Effect, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Acute, Mice, Mice, Inbred NOD, Mice, SCID, Transplantation, Homologous

JAX Source

J Leukoc Biol 2022 Feb; 111(2):427-437.

Volume

111

Issue

2

First Page

427

Last Page

437

ISSN

1938-3673

PMID

34057741

DOI

https://doi.org/10.1002/jlb.5ab0820-542rr

Abstract

The prognosis for acute myeloid leukemia (AML) relapse post allogeneic hematopoietic stem cell transplantation (alloSCT) is dismal. Novel effective treatment is urgently needed. Clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. The mechanisms that mediate immune escape of leukemia (thus causing GVL failure) remain poorly understood. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. Here, using our large, longitudinal clinical tissue bank that include AML cells and G-CSF mobilized donor hematopoietic stem cells (HSCs), we successfully established a novel GVL model in humanized mice. Donor HSCs were injected into immune-deficient NOD-Cg-Prkdc

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