Document Type

Article

Publication Date

1-1-2022

Publication Title

Front Immunol

Keywords

JMG, Cell Differentiation, Germinal Center, Receptors, CXCR5, T Follicular Helper Cells, T-Lymphocytes, Helper-Inducer

JAX Source

Front Immunol 2022 Apr14; 13:864949

Volume

13

First Page

864949

Last Page

864949

ISSN

1664-3224

PMID

35493515

DOI

https://doi.org/10.3389/fimmu.2022.864949

Grant

The Jackson Laboratory Director's Innovation Fund, The Mark Foundation for Cancer Research, The V Foundation, Pyewacket Fund

Abstract

T follicular helper (Tfh) cells provide support to B cells upon arrival in the germinal center, and thus are critical for the generation of a robust adaptive immune response. Tfh express specific transcription factors and cellular receptors including Bcl6, CXCR5, PD-1, and ICOS, which are critical for homing and overall function. Generally, the induction of an immune response is tightly regulated. However, deviation during this process can result in harmful autoimmunity or the inability to successfully clear pathogens. Recently, it has been shown that Tfh differentiation, activation, and proliferation may be linked with the cellular metabolic state. In this review we will highlight recent discoveries in Tfh differentiation and explore how these cells contribute to functional immunity in disease, including autoimmune-related disorders, cancer, and of particular emphasis, during infection.

Comments

We thank all members of the Chang Laboratory for critical feedback and discussion.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

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