Improving mouse models for the study of Alzheimer's disease.

Document Type

Article

Publication Date

2022

Publication Title

Current topics in developmental biology

Keywords

Aging, Alzheimer Disease, Animals, Disease Models, Animal, Genome-Wide Association Study, Mice, Neurodegenerative Diseases

JAX Source

Curr Top Dev Bill 2022; 148:79-113

Volume

148

First Page

79

Last Page

113

ISSN

1557-8933

PMID

35461569

DOI

https://doi.org/10.1016/bs.ctdb.2021.12.005

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disease whose risk is influenced by genetic and environmental factors. Although a number of pathological hallmarks have been extensively studied over the last several decades, a complete picture of disease initiation and progression remains unclear. We now understand that numerous cell types and systems are involved in AD pathogenesis, and that this cellular profile may present differently for each individual, making the creation of relevant mouse models challenging. However, with increasingly diverse data made available by genome-wide association studies, we can identify and examine new genes and pathways involved in genetic risk for AD, many of which involve vascular health and inflammation. When developing mouse models, it is critical to assess (1) an aging timeline that represents onset and progression in humans, (2) genetic variants and context, (3) environmental factors present in human populations that result in both neuropathological and functional changes-themes that we address in this chapter.

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