Mouse mutagenesis and phenotyping to generate models of development and disease.

Document Type

Article

Publication Date

1-1-2022

Publication Title

Current topics in developmental biology

Keywords

JMG, Animals, Genome, Male, Mammals, Mice, Mutagenesis, Spermatozoa

JAX Source

Curr Top Dev Biol. 2022;148:1-12

Volume

148

First Page

1

Last Page

12

ISSN

1557-8933

PMID

35461561

DOI

https://doi.org/10.1016/bs.ctdb.2022.02.012

Grant

OD023222

Abstract

For many years, the laboratory mouse has been the favored model organism to study mammalian development, biology and disease. Among its advantages for these studies are its close concordance with human biology, the syntenic relationship between the mouse and other mammalian genomes, the existence of many inbred strains, its short gestation period, its relatively low cost for housing and husbandry, and the wide array of tools for genome modification, mutagenesis, and for cryopreserving embryos, sperm and eggs. The advent of CRISPR genome modification techniques has considerably broadened the landscape of model organisms available for study, including other mammalian species. However, the mouse remains the most popular and utilized system to model human development, biology, and disease processes. In this review, we will briefly summarize the long history of mice as a preferred mammalian genetic and model system, and review current large-scale mutagenesis efforts using genome modification to produce improved models for mammalian development and disease.

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