Document Type
Article
Publication Date
1-21-2022
Publication Title
Nat Commun
Keywords
JGM, Adaptive Immunity, Aged, Antibodies, Monoclonal, Humanized, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, COVID-19, Cells, Cultured, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Immunity, Innate, Male, RNA-Seq, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, SARS-CoV-2, Single-Cell Analysis
JAX Source
Nat Comm 2022 Jan 21; 13(1):440
Volume
13
Issue
1
First Page
440
Last Page
440
ISSN
2041-1723
PMID
35064122
DOI
https://doi.org/10.1038/s41467-021-27716-4
Abstract
Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab. Coordinated profiling of gene expression and cell lineage protein markers shows that S100A
Recommended Citation
Unterman A,
Sumida T,
Nouri N,
Yan X,
Zhao A,
Gasque V,
Schupp J,
Asashima H,
Liu Y,
Cosme C,
Deng W,
Chen M,
Raredon M,
Hoehn K,
Wang G,
Wang Z,
DeIuliis G,
Ravindra N,
Li N,
Castaldi C,
Wong P,
Fournier J,
Bermejo S,
Sharma L,
Casanovas-Massana A,
Vogels C,
Wyllie A,
Grubaugh N,
Melillo A,
Meng H,
Stein Y,
Minasyan M,
Mohanty S,
Ruff W,
Cohen I,
Raddassi K,
Niklason L,
Ko A,
Montgomery R,
Farhadian S,
Iwasaki A,
Shaw A,
van Dijk D,
Zhao H,
Kleinstein S,
Hafler D,
Kaminski N,
Dela Cruz C.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nat Comm 2022 Jan 21; 13(1):440
Comments
This work is licensed under a Creative Commons Attribution 4.0 International License