Document Type
Article
Publication Date
1-21-2022
Publication Title
Nat Commun
Keywords
JGM, Adaptive Immunity, Aged, Antibodies, Monoclonal, Humanized, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, COVID-19, Cells, Cultured, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Immunity, Innate, Male, RNA-Seq, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, SARS-CoV-2, Single-Cell Analysis
JAX Source
Nat Comm 2022 Jan 21; 13(1):440
Volume
13
Issue
1
First Page
440
Last Page
440
ISSN
2041-1723
PMID
35064122
DOI
https://doi.org/10.1038/s41467-021-27716-4
Abstract
Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab. Coordinated profiling of gene expression and cell lineage protein markers shows that S100A
Recommended Citation
Unterman, Avraham; Sumida, Tomokazu S; Nouri, Nima; Yan, Xiting; Zhao, Amy Y; Gasque, Victor; Schupp, Jonas C; Asashima, Hiromitsu; Liu, Yunqing; Cosme, Carlos; Deng, Wenxuan; Chen, Ming; Raredon, Micha Sam Brickman; Hoehn, Kenneth B; Wang, Guilin; Wang, Zuoheng; DeIuliis, Giuseppe; Ravindra, Neal G; Li, Ningshan; Castaldi, Christopher; Wong, Patrick; Fournier, John; Bermejo, Santos; Sharma, Lokesh; Casanovas-Massana, Arnau; Vogels, Chantal B F; Wyllie, Anne L; Grubaugh, Nathan D; Melillo, Anthony; Meng, Hailong; Stein, Yan; Minasyan, Maksym; Mohanty, Subhasis; Ruff, William E; Cohen, Inessa; Raddassi, Khadir; Niklason, Laura E; Ko, Albert I; Montgomery, Ruth R; Farhadian, Shelli F; Iwasaki, Akiko; Shaw, Albert C; van Dijk, David; Zhao, Hongyu; Kleinstein, Steven H; Hafler, David A; Kaminski, Naftali; and Dela Cruz, Charles S, "Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19." (2022). Faculty Research 2022. 89.
https://mouseion.jax.org/stfb2022/89
Comments
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