Document Type

Article

Publication Date

1-21-2022

Publication Title

Nat Commun

Keywords

JGM, Adaptive Immunity, Aged, Antibodies, Monoclonal, Humanized, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, COVID-19, Cells, Cultured, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Immunity, Innate, Male, RNA-Seq, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, SARS-CoV-2, Single-Cell Analysis

JAX Source

Nat Comm 2022 Jan 21; 13(1):440

Volume

13

Issue

1

First Page

440

Last Page

440

ISSN

2041-1723

PMID

35064122

DOI

https://doi.org/10.1038/s41467-021-27716-4

Abstract

Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab. Coordinated profiling of gene expression and cell lineage protein markers shows that S100A

Comments

This work is licensed under a Creative Commons Attribution 4.0 International License

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