Plot twist: TET2 clones save the brain.

Authors

Maria Telpoukhovskaia, The Jackson LaboratoryFollow
Jennifer J. Trowbridge, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

8-7-2025

Original Citation

Telpoukhovskaia M, Trowbridge JJ. Plot twist: TET2 clones save the brain. Cell Stem Cell. 2025;32(8):1187-9

Keywords

JMG, Dioxygenases, Brain, Proto-Oncogene Proteins, Humans, DNA-Binding Proteins, Animals, Alzheimer Disease, Mutation, DNA Methyltransferase 3A

JAX Source

Cell Stem Cell. 2025;32(8):1187-9

ISSN

1875-9777

PMID

40780187

DOI

https://doi.org/10.1016/j.stem.2025.07.001

Abstract

While clonal hematopoiesis (CH) is associated with protection from Alzheimer’s disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al. discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.