Document Type
Article
Publication Date
5-5-2025
Original Citation
Hajjar J,
Voigt A,
Conner M,
Swennes A,
Fowler S,
Calarge C,
Mendonca D,
Armstrong D,
Chang C,
Walter J,
Butte M,
Savidge T,
Oh J,
Kheradmand F,
Petrosino J.
Gut dysbiosis patterns in CVID patients with noninfectious complications observed in a germ-free mouse model through fecal microbiota transplantation. J Hum Immun. 2025;1(1)
Keywords
JGM
JAX Source
J Hum Immun. 2025;1(1)
ISSN
3065-8993
PMID
41019955
DOI
https://doi.org/10.70962/jhi.20250040
Abstract
Patients with common variable immunodeficiency (CVID) who develop noninfectious complications (NIC) have worse clinical outcomes than those with infections only (INF). While gut microbiome aberrations have been linked to NIC, reductionist animal models that accurately recapitulate CVID are lacking. Our aim in this study was to uncover potential microbiome roles in the development of NIC in CVID. We performed whole-genome shotgun sequencing on fecal samples from CVID patients with NIC, INF, and their household controls. We also performed fecal microbiota transplants from CVID patients to germ-free mice. We found potentially pathogenic microbes
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