Document Type
Article
Publication Date
11-1-2025
Original Citation
Choi Y,
Shim M,
Kim S,
Kim D,
Jeong J,
Byeon J,
Jang G,
Kim J,
Robson P,
Lee C,
Lee H,
Jung K.
Single-cell transcriptomics of the myeloid milieu reveals an angiogenic niche in triple-negative breast cancer. Exp Mol Med. 2025;57(11):2487–504.
Keywords
JGM, Triple Negative Breast Neoplasms, Humans, Female, Single-Cell Analysis, Neovascularization, Pathologic, Animals, Tumor Microenvironment, Transcriptome, Mice, Myeloid Cells, Macrophages, Neutrophils, Vascular Endothelial Growth Factor A, Gene Expression Profiling, Gene Expression Regulation, Neoplastic
JAX Source
Exp Mol Med. 2025;57(11):2487–504.
ISSN
2092-6413
PMID
41203997
DOI
https://doi.org/10.1038/s12276-025-01571-5
Abstract
Intratumoral myeloid cells are highly heterogeneous in terms of development and function and are pivotal for forming and regulating the tumor microenvironment. However, the myeloid milieu in triple-negative breast cancer (TNBC) remains poorly understood. Here, to elucidate this myeloid milieu, we integrated in-house and public single-cell RNA sequencing data. We detected diverse neutrophil and mononuclear-phagocyte subtypes and delineated their developmental trajectories and functions. Of particular interest were the VEGFA
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.