Distinct mechanisms of dissemination of NDM-1 metallo- β-lactamase in

Mark D Adams, The Jackson Laboratory
Fernando Pasteran
German M Traglia
Jasmine Martinez
Fanny Huang
Christine Liu
Jennifer S Fernandez
Carolina Lopez
Lisandro J Gonzalez
Ezequiel Albornoz
Alejandra Corso
Alejandro J Vila
Robert A Bonomo
Maria Soledad Ramirez

Abstract

A four-year surveillance of carbapenem-resistant Acinetobacter spp. in Argentina identified 40 strains carrying bla NDM-1Genome sequencing revealed that most were A. baumannii, while seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-baumannii strains. A resistance gene island carrying bla PER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains