Inflammasome as an Inflammatory Response to Ocular Hypertension
Document Type
Article
Publication Date
Summer 2018
JAX Location
In: Student Reports, Summer 2018, The Jackson Laboratory
Sponsor
Dr. Simon John and Dr. Jeffrey Harder
Abstract
Glaucoma is the leading cause of irreversible blindness worldwide. One of the strongest risk factors for the disease is ocular hypertension. A symptom of the disease is an accumulation of inflammation related proteins in the retina and optic nerve. One such protein is ASC, a key component of inflamniasomes. This paper investigates a natural progression model of glaucoma as well as acute models of elevated intraocular pressure to examine the expression of inflammasome proteins in response to ocular hypertension. The results suggest the inflammasome expression is directly caused by elevated intraocular pressure.
Recommended Citation
Feist, Annabelle, "Inflammasome as an Inflammatory Response to Ocular Hypertension" (2018). Summer and Academic Year Student Reports. 2600.
https://mouseion.jax.org/strp/2600