Inflammasome as an Inflammatory Response to Ocular Hypertension


Annabelle Feist

Document Type


Publication Date

Summer 2018

JAX Location

In: Student Reports, Summer 2018, The Jackson Laboratory


Glaucoma is the leading cause of irreversible blindness worldwide. One of the strongest risk factors for the disease is ocular hypertension. A symptom of the disease is an accumulation of inflammation related proteins in the retina and optic nerve. One such protein is ASC, a key component of inflamniasomes. This paper investigates a natural progression model of glaucoma as well as acute models of elevated intraocular pressure to examine the expression of inflammasome proteins in response to ocular hypertension. The results suggest the inflammasome expression is directly caused by elevated intraocular pressure.

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