The Expression of ZFHX4 Protein in Developing Mouse Lungs and Lung Adenocarcinoma

Tina Li

Document Type

Article

Publication Date

Summer 2022

Keywords

JMG

JAX Location

In: Student Reports, Summer 2022, The Jackson Laboratory

Abstract

Zinc finger homeobox 4 (ZFHX4) is a candidate gene for Congenital Diaphragmatic Hernia (CDH), and mutations within ZFHX4 have been observed to cause lung and craniofacial phenotypes in mice (unpublished data). In addition to ZFHX4’s potential role in CDH, genomic data from human lung tumors reveals that ZFHX4 is commonly mutated in lung adenocarcinoma (LUAD), a subtype of lung cancer. The goals of this research are to use immunofluorescence to (1) document when and where ZFHX4 protein is expressed in developing mouse lungs, and (2) document where ZFHX4 is expressed in the lung adenocarcinomas in a mouse model of lung cancer. In developing mouse lungs, ZFHX4 expression was highest at E15.5. In KP mouse lung tumors, ZFHX4 expression was inconclusive, and further investigation on the reactivation and expression of ZFHX4 needs to be conducted. The results of this research will aid in the understanding of the function of ZFHX4 and its role in lung cancer.

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