Spatial transcriptomics for assessing the diabetic kidney

Jingyan Zhang

Document Type

Article

Publication Date

2025

Keywords

JGM

Abstract

The human kidneys are a vital organ for proper systemic function in the body by maintaining blood chemical composition. However, the ability to properly filter blood decreases as individuals age, which is characterized at a cellular level in a phenomenon deemed senescence, occurring when cells do not divide, nor die. Such cells have unique inflammatory and secretory profiles that are still being studied. In order to relate the cellular level of transcriptomic data with higher level tissue-level structure and patterns, Xenium data can be leveraged for discovery about aging and senescence in the kidneys, as genetic data can be mapped back to a spatially-relevant context. We characterized the genetic profiles of Xenium 5K kidney images and discovered insights into the aging kidney structures crucial for function and affecting disease onset.

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