Human Circulating Hematopoietic Stem and Progenitor Cells Show Transcriptional Changes with Aging

Document Type

Article

Publication Date

2026

JAX Location

JGM

Abstract

As adults age, their immune systems become more prone to chronic inflammation, a process known as inflammaging. This process has been linked to changes in hematopoietic stem and progenitor cells (HSPCs), which give rise to all mature immune cells. While most HSPCs reside in the bone marrow or spleen, a subset, called cHSPCs, live in the circulatory system. This study uses two scRNA-seq datasets to characterize how cHSPCs change with age. We annotated cHSPC subtypes based on their transcriptional profiles, identified differentially expressed genes and pathways between young and older adults cHSPCs, and uncovered changes in frequency of cHSPC subtypes of older adults. Overall, we found that cHSPCs show reduced proliferative potential, and higher expression of deleterious genes and pathways with age.

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