Effect of age on intestinal radiosensitivity.

Donna Huang

Document Type

Article

Publication Date

1967

JAX Location

In: COLLEGE STUDENT REPORTS, 1967 PART I, JACKSON LABORATORY

Abstract

C57Bl/6J female mice, ranging in age frQm 3 to 2 ~ months, were used to study the relationship between age and intestinal radiosensitivity. Deathl from bone marrow damage was prevented either by isologous marrow transplantation or by upper-body shielding. The percent survival and survival times in these two treatme~t groups(after x-ray dosages expected to induce inte~tinal mortality)are found +a be negatively correlated with age. Increasing the x-ray dose gave the same relation within an age group. The extent of intestinal recovery within 2'4 hours following a constant 400R dose of irradiation was studied with respect to age by tpe classic split-dose method. An inverse linear relation was found between age and percent of recovery. Based on the above observations it is concluded that in aging populations the int~stinal sensitivity plays a more significant role in the overall lethality-measured radiosensitivity. The increaee of intestinal sensitivity With age may be the result of a lesser extent of recovery from radiation-induced injury.

Comments

Summer, 1967

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