Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
Animal, Chromosome-Mapping, Crosses-Genetic, Genetic-Marker, Leishmaniasis-Visceral: fg, im, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S
Clin-Exp-Immunol. 1979 Jul; 37(1):7-14.
Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.
Bradley, D J.; Taylor, B A.; Blackwell, J; Evans, E P.; and Freeman, J, " Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse." (1979). Faculty Research 1970 - 1979. 1009.
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