Faculty Research 1970 - 1979

Title

Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.

Document Type

Article

Publication Date

1979

Keywords

Animal, Chromosome-Mapping, Crosses-Genetic, Genetic-Marker, Leishmaniasis-Visceral: fg, im, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S

JAX Location

43,206

JAX Source

Clin-Exp-Immunol. 1979 Jul; 37(1):7-14.

Abstract

Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.

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