Faculty Research 1970 - 1979

Title

Marked reduction of spectrinin hereditary spherocytosis in the common house mouse.

Document Type

Article

Publication Date

1978

Keywords

Electrophoresis-Polyacrylamide-Gel, Erythrocyte-Membrane, Membrane-Proteins: df, Mice, Peptides, Spectrin: df, Spherocytes, Spherocytosis-Hereditary: bl, fg, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Blood. 1978 Jun; 51(6):1149-55.

Abstract

In contrast to the disease in humans, hereditary spherocytosis in the common house mouse produces an extreme spherocytosis. The cells show a broad distribution in size ranging from microcytic to macrocytic. Of particular interest is the finding of a substantial reduction in the major membrane polypeptide called spectrin, supporting a critical role for this protein in the control of erythrocyte shape and membrane stability.

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