Faculty Research 1970 - 1979
Marked reduction of spectrinin hereditary spherocytosis in the common house mouse.
Document Type
Article
Publication Date
1978
Keywords
Electrophoresis-Polyacrylamide-Gel, Erythrocyte-Membrane, Membrane-Proteins: df, Mice, Peptides, Spectrin: df, Spherocytes, Spherocytosis-Hereditary: bl, fg, SUPPORT-U-S-GOVT-P-H-S
First Page
1149
Last Page
1155
JAX Source
Blood. 1978 Jun; 51(6):1149-55.
Abstract
In contrast to the disease in humans, hereditary spherocytosis in the common house mouse produces an extreme spherocytosis. The cells show a broad distribution in size ranging from microcytic to macrocytic. Of particular interest is the finding of a substantial reduction in the major membrane polypeptide called spectrin, supporting a critical role for this protein in the control of erythrocyte shape and membrane stability.
Recommended Citation
Greenquist AC,
Shohet SB,
Bernstein SE.
Marked reduction of spectrinin hereditary spherocytosis in the common house mouse. Blood. 1978 Jun; 51(6):1149-55.