Faculty Research 1970 - 1979
T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.
Document Type
Article
Publication Date
1979
Keywords
Cytotoxicity-Immunologic, Genes-Immune-Response, H-2-Antigens: ge, Isoantigens: ge, Leukocyte-Culture-Test-Mixed, Lymphocyte-Transformation, Mice, Mutation, Phenotype, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im
First Page
3455
Last Page
3459
JAX Source
Proc-Natl-Acad-Sci-USA. 1979 Jul; 76(7):3455-9.
Abstract
The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+ T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.
Recommended Citation
Wettstein PJ,
Bailey DW,
Mobraaten LE,
Klein J,
Frelinger JA.
T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+. Proc-Natl-Acad-Sci-USA. 1979 Jul; 76(7):3455-9.