Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers.

Authors

J E. Womack
N L. Hawes
E R. Soares
T H. Roderick

Document Type

Article

Publication Date

1975

Keywords

Animal, Chromosome-Mapping, Crosses-Genetic, Female, Genotype, Glucuronidase: an, Kidney: en, Linkage-(Genetics), Malate-Dehydrogenase: an, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C57BL, Mitochondria: en, Recombination-Genetic, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

First Page

519

Last Page

525

JAX Source

Biochem-Genet. 1975 Oct; 13(9-10):519-25.

Abstract

Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described. We have located this locus 11.0 +/- 2.9 cM from the beta-glucuronidase structural gene, Gus, on chromosome 5. The gene order is Hm-Pgm-1-rd-bf-Gus-Mor-1. Thus Mor-1 is presently the most distal marker on chromosome 5. Three different nuclear loci for mitochondrial enzymes (Mod-2, Got-2, and Mor-1) have now been mapped in the mouse, all on different chromosomes.

Recommended Citation

Womack JE, Hawes NL, Soares ER, Roderick TH. Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers. Biochem-Genet. 1975 Oct; 13(9-10):519-25.