Faculty Research 1970 - 1979
Genes associated with leukocyte production in mice.
Document Type
Article
Publication Date
1975
Keywords
Crosses-Genetic, Genes, Hematopoiesis, Hybridization, Leukocyte-Count, Leukocytes, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S
First Page
301
Last Page
308
JAX Location
41,016
JAX Source
J-Hered. 1975 Sep-Oct; 66(5):301-8.
Abstract
We have investigated the genes influencing leukocyte production in mice by selective breeding for differences in leukocyte count and developed two major lines differing about 8-fold. In these lines we have made counter selective breeding, crossbreeding between them, and developed methods of using marker genes to search for individual genes distributed on different chromosomes. We have revealed an overall dominance of genes for low leukocyte count over those for high counts, and effects of genes at the agouti locus, certain mutant genes, and a gene or genes in the XVI linkage group. We have commented on the application and approach of quantitative genetic experimentation from both a theoretical and practical point of view and, on the basis of present results, discussed the nature of polygenes in relation to genes causing polymorphisms.
Recommended Citation
Chai CK.
Genes associated with leukocyte production in mice. J-Hered. 1975 Sep-Oct; 66(5):301-8.