Faculty Research 1970 - 1979

Hereditary vestigial pulmonary arterial trunk and related defects in rabbits.

Document Type

Article

Publication Date

1975

Keywords

Animals-Newborn, Aortic-Coarctation, Aortic-Valve-Stenosis, Birth-Weight, Disease-Models-Animal, Female, Genes-Lethal, Genes-Recessive, Genetics-Population, Heart-Defects-Congenital: fg, Heart-Septal-Defects-Ventricular: fg, Litter-Size, Male, Pregnancy, Pulmonary-Artery: ab, Pulmonary-Valve-Stenosis: cn, Rabbits, SUPPORT-U-S-GOVT-P-H-S

First Page

50

Last Page

55

JAX Location

40,726

JAX Source

J-Hered. 1975 Mar-Apr; 66(2):50-5.

Abstract

In a population of IIIVO/J rabbits at the Jackson Laboratory a vestigial pulmonary arterial trunk is the commonest expression of a malformation involving the heart and great vessels. There appears to be a series of effects from a completely absent pulmonary trunk through a vestigial but patent pulmonary trunk and/or pulmonary valve stenosis on the one hand to a vestigial or absent ascending aorta on the other. In a few cases the pulmonary trunk is bulbous and the ductus arteriosus is vestigial or absent. In almost all cases of this syndrome, there is also a high ventricular septal defect. The animals appear perfectly normal in every other respect. In its extreme forms this mutation is lethal, but those few animals that are somewhat less severely affected may live for a short time. No effect was seen on birth weight or litter size. Inheritance of vestigial pulmonary arterial trunk appears to be due to two autosomal recessive factors both of which must be homozygous for the expression of the condition. We propose the symbols vpt-1 and vpt-2 for the genes responsible for vestigial pulmonary arterial trunk and its related abnormalities.

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