Genetic determination of the alpha-galactosidase developmental program in mice.

Authors

A J. Lusis
K PaigenFollow

Document Type

Article

Publication Date

1975

Keywords

Animal, Brain: en, gd, Galactosidases: me, Genes-Structural, Heart: gd, Liver: en, gd, Lysosomes: en, Macromolecular-Systems, Mice, Mice-Inbred-Strains: me, Myocardium: en, SUPPORT-U-S-GOVT-P-H-S

First Page

371

Last Page

378

JAX Source

Cell 1975 Nov; 6(3):371-8.

Abstract

The expression of alpha-galactosidase in liver, heart, and brain during postembryonic development has been examined in several inbred mouse strains. In most strains, the developmental patterns of alpha-galactosidase are coordinate with those of two other acid hydrolases, beta-glucuronidase and beta-galactosidase. Certain inbred mouse strains, including members of the C57-C58 family, have a tissue-specific alteration in the temporal expression of alpha-galactosidase activity. This alteration shows additive inheritance and appears to be controlled by a single genetic locus. The altered developmental expression of the enzyme is not accompanied by any discernible change in its physical properties.

Recommended Citation

Lusis AJ, Paigen K. Genetic determination of the alpha-galactosidase developmental program in mice. Cell 1975 Nov; 6(3):371-8.