Faculty Research 1970 - 1979

Genetic determination of the alpha-galactosidase developmental program in mice.

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Animal, Brain: en, gd, Galactosidases: me, Genes-Structural, Heart: gd, Liver: en, gd, Lysosomes: en, Macromolecular-Systems, Mice, Mice-Inbred-Strains: me, Myocardium: en, SUPPORT-U-S-GOVT-P-H-S

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Cell 1975 Nov; 6(3):371-8.


The expression of alpha-galactosidase in liver, heart, and brain during postembryonic development has been examined in several inbred mouse strains. In most strains, the developmental patterns of alpha-galactosidase are coordinate with those of two other acid hydrolases, beta-glucuronidase and beta-galactosidase. Certain inbred mouse strains, including members of the C57-C58 family, have a tissue-specific alteration in the temporal expression of alpha-galactosidase activity. This alteration shows additive inheritance and appears to be controlled by a single genetic locus. The altered developmental expression of the enzyme is not accompanied by any discernible change in its physical properties.

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