A new allele of ocular retardation: early development and morphogenetic cell death.

Authors

K Theiler
D S. Varnum
J H. Nadeau
L C. Stevens
B Cagianut

Document Type

Article

Publication Date

1976

Keywords

Animal, Eye: ab, Mice, Mice-Inbred-Strains, Microscopy-Electron, Optic-Nerve: ab, Retina: ab, pa, SUPPORT-U-S-GOVT-P-H-S

First Page

85

Last Page

97

JAX Source

Anat-Embryol-(Berl). 1976 Dec 22; 150(1):85-97.

Abstract

The inheritance and some developmental effects of a new allele of ocular retardation (orJ) are described. Affected animals or 12 days of gestation, show reduced cell death in the eye cup and thickening of the inner wall of the optic fissure. At 11 to 13 dyas of gestation orJ/orJ eyes grafted to the testis do not produce retina as their orJ+ littermates do. Adult animals have small eyes with closed lids, abnormal retinal layers, and no optic nerve.

Recommended Citation

Theiler K, Varnum DS, Nadeau JH, Stevens LC, Cagianut B. A new allele of ocular retardation: early development and morphogenetic cell death. Anat-Embryol-(Berl). 1976 Dec 22; 150(1):85-97.