Faculty Research 1970 - 1979
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.
Document Type
Article
Publication Date
1978
Keywords
Antigens, Cytotoxicity-Tests-Immunologic, H-2-Antigens, Immune-Sera, Leukocyte-Culture-Test-Mixed, Mice, Mutation, Phenotype, T-Lymphocytes: im
First Page
1395
Last Page
1404
JAX Source
J-Exp-Med. 1978 May 1; 147(5):1395-1404.
Abstract
We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.
Recommended Citation
Wettstein PJ,
Bailey DW,
Mobraaten LE,
Klein J,
Frelinger JA.
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells. J-Exp-Med. 1978 May 1; 147(5):1395-1404.