Faculty Research 1970 - 1979
Study on the mutagenicity of conjugated estrogens in human, animal and bacterial systems.
Document Type
Article
Publication Date
1978
Keywords
Burkitt's-Lymphoma, Carcinogens, Cell-Line, Chromosome-Aberrations, Estrogenic-Substances-Conjugated: ae, Hamsters, Human, Mice, Mutagens, Mutation, Salmonella-Typhimurium: de, ph
First Page
423
Last Page
432
JAX Source
J Med 1978; 9(5):423-32.
Abstract
Conjugated estrogens were studied for mutagenicity (and implied carcinogenicity) in two strains of S. typhimurium, two normal and three neoplastic human lymphoid cell lines (the latter from Burkitt's lymphoma patients) in cell culture and a Chinese hamster cell line in diffusion chambers implanted into mice. No significant increase in mutation rate or chromosome aberrations were noticed after exposure to conjugated estrogens.
Recommended Citation
Sirianni SR,
Hale P,
Brown M,
Huang CC,
Paigen B,
Ambrus JL.
Study on the mutagenicity of conjugated estrogens in human, animal and bacterial systems. J Med 1978; 9(5):423-32.