Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.
Document Type
Article
Publication Date
2010
Keywords
Antibodies, Antigens-CD4, Contrast-Media, Gold, Lymph-Nodes, Mice, Nanoparticles, Tomography-X-Ray-Computed
First Page
2318
Last Page
2322
JAX Location
see Reprint collection, a pdf is available
JAX Source
Nano Lett 2010 Jul; 10(7):2318-22.
Abstract
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.
Recommended Citation
Eck W,
Nicholson AI,
Zentgraf H,
Semmler W,
Bartling S.
Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett 2010 Jul; 10(7):2318-22.