Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.
Antibodies, Antigens-CD4, Contrast-Media, Gold, Lymph-Nodes, Mice, Nanoparticles, Tomography-X-Ray-Computed
see Reprint collection, a pdf is available
Nano Lett 2010 Jul; 10(7):2318-22.
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.
Eck, W; Nicholson, A I.; Zentgraf, H; Semmler, W; and Bartling, S, "Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice." (2010). Faculty Research 2010. 112.