Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.
Document Type
Article
Publication Date
2010
Keywords
Crossing-Over-Genetic, Fertility, Germ-Cells, Humans, Mammals, Meiosis, Models-Genetic
First Page
124
Last Page
136
JAX Source
Nat Rev Genet 2010 Feb; 11(2):124-36.
Abstract
Meiosis is an essential stage in gamete formation in all sexually reproducing organisms. Studies of mutations in model organisms and of human haplotype patterns are leading to a clearer understanding of how meiosis has adapted from yeast to humans, the genes that control the dynamics of chromosomes during meiosis, and how meiosis is tied to gametic success. Genetic disruptions and meiotic errors have important roles in infertility and the aetiology of developmental defects, especially aneuploidy. An understanding of the regulation of meiosis, coupled with advances in genomics, may ultimately allow us to diagnose the causes of meiosis-based infertilities, more wisely apply assisted reproductive technologies, and derive functional germ cells.
Recommended Citation
Handel MA,
Schimenti JC.
Genetics of mammalian meiosis: regulation, dynamics and impact on fertility. Nat Rev Genet 2010 Feb; 11(2):124-36.