Phenotype ontologies for mouse and man: bridging the semantic gap.
Document Type
Article
Publication Date
2010
Keywords
Disease, Disease-Models-Animal, Humans, Mice, Phenotype, Semantics, Species-Specificity
First Page
281
Last Page
289
JAX Source
Dis Model Mech 2010 May-Jun; 3(5-6):281-9.
Abstract
A major challenge of the post-genomic era is coding phenotype data from humans and model organisms such as the mouse, to permit the meaningful translation of phenotype descriptions between species. This ability is essential if we are to facilitate phenotype-driven gene function discovery and empower comparative pathobiology. Here, we review the current state of the art for phenotype and disease description in mice and humans, and discuss ways in which the semantic gap between coding systems might be bridged to facilitate the discovery and exploitation of new mouse models of human diseases.
Recommended Citation
Schofield PN,
Gkoutos GV,
Gruenberger M,
Sundberg JP,
Hancock JM.
Phenotype ontologies for mouse and man: bridging the semantic gap. Dis Model Mech 2010 May-Jun; 3(5-6):281-9.