Orthology for comparative genomics in the mouse genome database.
Document Type
Article
Publication Date
8-2015
JAX Source
Mamm Genome 2015 Aug; 26(7-8):305-313
Volume
26
Issue
7-8
First Page
305
Last Page
313
ISSN
1432-1777
PMID
26223881
Grant
HG000330, HG002273, HD062499
Abstract
The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, MGD has included comparative genomics data with a particular focus on human-mouse orthology, an essential component of the use of mouse as a model organism. Over the past 25 years, novel algorithms and addition of orthologs from other model organisms have enriched comparative genomics in MGD data, extending the use of orthology data to support the laboratory mouse as a model of human biology. Here, we describe current comparative data in MGD and review the history and refinement of orthology representation in this resource. Mamm Genome 2015 Aug; 26(7-8):305-313
Recommended Citation
Dolan ME,
Baldarelli RM,
Bello SM,
Ni L,
McAndrews MS,
Bult CJ,
Kadin JA,
Richardson JE,
Ringwald M,
Eppig JT,
Blake JA.
Orthology for comparative genomics in the mouse genome database. Mamm Genome 2015 Aug; 26(7-8):305-313