Mouse Genome Database: From sequence to phenotypes and disease models.

Document Type

Article

Publication Date

8-2015

JAX Source

Genesis 2015 Aug; 53(8):458-73.

Volume

53

Issue

8

First Page

458

Last Page

473

ISSN

1526-968X

PMID

26150326

Grant

HG000330

Abstract

The Mouse Genome Database (MGD, www.informatics.jax.org) is the international scientific database for genetic, genomic, and biological data on the laboratory mouse to support the research requirements of the biomedical community. To accomplish this goal, MGD provides broad data coverage, serves as the authoritative standard for mouse nomenclature for genes, mutants, and strains, and curates and integrates many types of data from literature and electronic sources. Among the key data sets MGD supports are: the complete catalog of mouse genes and genome features, comparative homology data for mouse and vertebrate genes, the authoritative set of Gene Ontology (GO) annotations for mouse gene functions, a comprehensive catalog of mouse mutations and their phenotypes, and a curated compendium of mouse models of human diseases. Here, we describe the data acquisition process, specifics about MGD's key data areas, methods to access and query MGD data, and outreach and user help facilities. genesis 53:458-473, 2015. © 2015 The Authors. Genesis Published by Wiley Periodicals, Inc.

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