miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.
Document Type
Article
Publication Date
11-2015
JAX Source
Trends Genet 2015 Nov; 31(11):613-26.
Volume
31
Issue
11
First Page
613
Last Page
626
ISSN
0168-9525
PMID
26453491
Grant
5P41HG000330
Abstract
High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of miRNAs to encompass this diversity. We then review nomenclature guidelines for miRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of small RNA sequencing experiments. Trends Genet 2015 Nov; 31(11):613-26.
Recommended Citation
Desvignes T,
Batzel P,
Berezikov E,
Eilbeck K,
Eppig JT,
McAndrews MS,
Singer A,
Postlethwait J.
miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants. Trends Genet 2015 Nov; 31(11):613-26.