Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK.

Authors

Siyuan Dai, The Jackson LaboratoryFollow
Zijian Tang, The Jackson LaboratoryFollow
Junyue Cao, The Jackson LaboratoryFollow
Wei Zhou, The Jackson LaboratoryFollow
Huawen Li, The Jackson LaboratoryFollow
Stephen B. Sampson, The Jackson LaboratoryFollow
Chengkai Dai, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

2-3-2015

JAX Source

EMBO J 2015 Feb 3; 34(3):275-93.

Volume

34

Issue

3

First Page

275

Last Page

293

ISSN

1460-2075

PMID

25425574

Grant

CA034196

Abstract

Numerous extrinsic and intrinsic insults trigger the HSF1-mediated proteotoxic stress response (PSR), an ancient transcriptional program that is essential to proteostasis and survival under such conditions. In contrast to its well-recognized mobilization by proteotoxic stress, little is known about how this powerful adaptive mechanism reacts to other stresses. Surprisingly, we discovered that metabolic stress suppresses the PSR. This suppression is largely mediated through the central metabolic sensor AMPK, which physically interacts with and phosphorylates HSF1 at Ser121. Through AMPK activation, metabolic stress represses HSF1, rendering cells vulnerable to proteotoxic stress. Conversely, proteotoxic stress inactivates AMPK and thereby interferes with the metabolic stress response. Importantly, metformin, a metabolic stressor and popular anti-diabetic drug, inactivates HSF1 and provokes proteotoxic stress within tumor cells, thereby impeding tumor growth. Thus, these findings uncover a novel interplay between the metabolic stress sensor AMPK and the proteotoxic stress sensor HSF1 that profoundly impacts stress resistance, proteostasis, and malignant growth. EMBO J 2015 Feb 3; 34(3):275-93.

Recommended Citation

Dai S, Tang Z, Cao J, Zhou W, Li H, Sampson SB, Dai C. Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK. EMBO J 2015 Feb 3; 34(3):275-93.