A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells.
Document Type
Article
Publication Date
1-1-2015
JAX Source
Genes Dev 2015 Jan 1; 29(1):1-6.
Volume
29
Issue
1
First Page
1
Last Page
6
ISSN
1549-5477
PMID
25561492
Abstract
Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the α5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer. Genes Dev 2015 Jan 1; 29(1):1-6.
Recommended Citation
Chang C,
Goel H,
Gao H,
Pursell B,
Shultz LD,
Greiner D,
Ingerpuu S,
Patarroyo M,
Cao S,
Lim E,
Mao J,
McKee K,
Yurchenco P,
Mercurio A.
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. Genes Dev 2015 Jan 1; 29(1):1-6.