Applying the ARRIVE Guidelines to an In Vivo Database.
Document Type
Article
Publication Date
5-20-2015
JAX Source
PLoS Biol 2015 May 20; 13(5):e1002151.
Volume
13
Issue
5
First Page
1002151
Last Page
1002151
ISSN
1545-7885
PMID
25992600
Abstract
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future. PLoS Biol 2015 May 20; 13(5):e1002151.
Recommended Citation
Karp N,
Meehan T,
Morgan H,
Mason J,
Blake A,
Kurbatova N,
Smedley D,
Jacobsen J,
Mott R,
Iyer V,
Matthews P,
Melvin D,
Wells S,
Flenniken A,
Masuya H,
Wakana S,
White J,
Lloyd K,
Reynolds C,
Paylor R,
West D,
Svenson KL,
Chesler EJ,
de Angelis M,
Tocchini-Valentini G,
Sorg T,
Herault Y,
Parkinson H,
Mallon A,
Brown S.
Applying the ARRIVE Guidelines to an In Vivo Database. PLoS Biol 2015 May 20; 13(5):e1002151.