Visual impairment in an optineurin mouse model of primary open-angle glaucoma.
Document Type
Article
Publication Date
6-1-2015
JAX Source
Neurobiol Aging 2015 Jun; 36(6):2201-12.
Volume
36
Issue
6
First Page
2201
Last Page
2212
ISSN
1558-1497
PMID
25818176
Abstract
Primary open-angle glaucoma (POAG) is characterized by progressive neurodegeneration of retinal ganglion cells (RGCs). Why RGCs degenerate in low-pressure POAG remains poorly understood. To gain mechanistic insights, we developed a novel mouse model based on a mutation in human optineurin associated with hereditary, low-pressure POAG. This mouse improves the design and phenotype of currently available optineurin mice, which showed high global overexpression. Although both 18-month-old optineurin and nontransgenic control mice showed an age-related decrease in healthy axons and RGCs, the expression of mutant optineurin enhanced axonal degeneration and decreased RGC survival. Mouse visual function was determined using visual evoked potentials, which revealed specific visual impairment in contrast sensitivity. The E50K optineurin transgenic mouse described here exhibited clinical features of POAG and may be useful for mechanistic dissection of POAG and therapeutic development. Neurobiol Aging 2015 Jun; 36(6):2201-12.
Recommended Citation
Tseng H,
Riday T,
McKee C,
Braine C,
Bomze H,
Barak I,
Marean-Reardon C,
John S,
Philpot B,
Ehlers M.
Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging 2015 Jun; 36(6):2201-12.